Frequency detection and temporally dispersed synaptic signal association through a metabotropic glutamate receptor pathway

摘要: In the classical view, a central neuron integrates incoming synaptic information by simple algebraic summation of resultant bioelectrical signals that coincide in time. The voltage dependence NMDA (N-methyl-D-aspartate) type ionotropic glutamate receptor endows neurons with an additional tool allows one input to influence another, providing, again, two are active simultaneously. Here we identify new mechanism which non-coincident generated different inputs integrated. device serves regulate neuronal excitation through G-protein-coupled, metabotropic receptors (mGluRs) powerful and specific manner. We show that, cerebellar Purkinje cells, single activation climbing-fibre markedly potentiates mGluR-mediated at parallel-fibre synapses. potentiation results from transient rise cytosolic Ca2+ is 'memorized' such way it promotes mGluRs for about minutes. A Ca2+-transient also effective if imposed up seconds after stimulation. By allowing temporally spatially dispersed be assimilated, this adds element computational power neurons.