Montelukast, a leukotriene receptor antagonist abrogates lipopolysaccharide-induced toxicity and oxidative stress in rat liver.

作者: Ahmed M. Mohamadin , Ahmed A. Elberry , Mohamed A. Elkablawy , Hala S. Abdel Gawad , Fahad A. Al-Abbasi

DOI: 10.1016/J.PATHOPHYS.2011.02.003

关键词: Oxidative stressGlutathioneSuperoxide dismutaseBiochemistryPharmacologyLiver injuryReactive oxygen speciesMalondialdehydeMyeloperoxidaseGlutathione peroxidaseChemistry

摘要: … protein, GSH and enzymatic antioxidants (CAT, SOD and GSH-Px)… levels of serum enzymes indicating cellular leakage and loss of … In this study, MNT inhibited MPO activity which was …

参考文章(41)
O'Byrne Pm, Asthma treatment: antileukotriene drugs. Canadian Respiratory Journal. ,(1998)
A. Srivastava, J. L. Maggs, D. J. Antoine, D. P. Williams, D. A. Smith, B. K. Park, Role of Reactive Metabolites in Drug-Induced Hepatotoxicity Handbook of Experimental Pharmacology. ,vol. 196, pp. 165- 194 ,(2010) , 10.1007/978-3-642-00663-0_7
H Vapaatalo, R Holma, I Virtanen, P Salmenperä, R Korpela, Prophylactic potential of montelukast against mild colitis induced by dextran sulphate sodium in rats Journal of Physiology and Pharmacology. ,vol. 58, pp. 455- 467 ,(2007)
Hugo Aebi, Catalase in vitro Methods in Enzymology. ,vol. 105, pp. 121- 126 ,(1984) , 10.1016/S0076-6879(84)05016-3
Rodney L. Levine, Donita Garland, Cynthia N. Oliver, Adolfo Amici, Isabel Climent, Anke-G. Lenz, Bong-Whan Ahn, Shmuel Shaltiel, Earl R. Stadtman, Determination of carbonyl content in oxidatively modified proteins. Methods in Enzymology. ,vol. 186, pp. 464- 478 ,(1990) , 10.1016/0076-6879(90)86141-H
K F Austen, J D Williams, J K Czop, Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators. Journal of Immunology. ,vol. 132, pp. 3034- 3040 ,(1984)
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Ömer Coşkun, Antioxidant and Hepatoprotective Activity of Vitamin E and EGb 761 in Experimental Endotoxemic Rats Turkish Journal of Medical Sciences. ,vol. 30, pp. 427- 432 ,(2000)
J. L. Wallace, P. L. Beck, G. P. Morris, Is there a role for leukotrienes as mediators of ethanol-induced gastric mucosal damage? American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 254, ,(1988) , 10.1152/AJPGI.1988.254.1.G117
Astrid Haegens, Peter Heeringa, Robert Jan van Suylen, Chad Steele, Yasuaki Aratani, Robert J. J. O'Donoghue, Steven E. Mutsaers, Brooke T. Mossman, Emiel F. M. Wouters, Juanita H. J. Vernooy, Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production Journal of Immunology. ,vol. 182, pp. 7990- 7996 ,(2009) , 10.4049/JIMMUNOL.0800377