Atorvastatin inhibits osteoclastogenesis and arrests tooth movement.
作者： Gabriel Schmidt Dolci , Ana Ballarini , Gustavo Hauber Gameiro , Diogo Onofre de Souza , Fabiana de Melo
DOI: 10.1016/J.AJODO.2017.09.021
关键词: Endochondral ossification 、 Endocrinology 、 Bone resorption 、 Statin 、 H&E stain 、 Femur 、 Atorvastatin 、 Osteoclast 、 Internal medicine 、 Bone remodeling 、 Medicine
摘要: Introduction In addition to their cholesterol-lowering effects, the statin class of drugs appears enhance osteogenesis and suppress bone resorption, which could be a clinical concern during orthodontic treatment. this animal study, we aimed determine whether atorvastatin (ATV) affects tooth movement (OTM) through osteoclast inhibition. Furthermore, analyzed potential adverse effects ATV on long-bone turnover endochondral ossification. Methods Rats were administered (15 mg/kg) or saline solution via gavage (n = 12 animals/group), starting 2 weeks before initial OTM. Tooth displacement was measured after 7, 14, 21 days. Histologic sections maxilla femur obtained 14 21 days OTM stained (hematoxylin eosin; TRAP assay) for histomorphometric analysis. Results associated with significant ( P Conclusions This experimental study showed that long-term use can significantly promote inhibition slow in first week rats. Under physiologic conditions, drug did not affect
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