Plant-derived Glycosides with α-Glucosidase Inhibitory Activity: Current Standing and Future Prospects.
作者： Haroon Khan , Surrya Amin , Devesh Tewari , Seyed M Nabavi , Atanas G Atanasov
DOI: 10.2174/1871530319666181128104831
关键词: Acarbose 、 Brush border 、 Small intestine 、 Enzyme 、 Glycoside 、 Biology 、 Pharmacology 、 In vitro 、 α glucosidase inhibitory 、 Effective management
摘要: BACKGROUND The α-glucosidase (EC 3.2.1.20), a calcium-containing intestinal enzyme which is positioned in the cells cover microvilli brush border. carbohydrates require metabolism by before being absorbed into small intestine, and as result, this represents significant drug target for effective management of diabetes. There are few α- glucosidase inhibitors clinical practice that challenged several limitations. Thus, new safe therapeutic agents class required. In regard, plant secondary metabolites very promising source to be investigated. Herein review, we have focused on preclinical studies various glycosides with vitro inhibitory activity. METHODS literature available websites such GoogleScholar, PubMed, Scopus. All peer-reviewed articles were included without considering impact factor. RESULTS surveyed revealed marked profile derived from plants, some them extremely potent relatively standard, acarbose trials exhibited multiple targeted effects. CONCLUSION Keeping view results, these strong candidates further, more detailed ascertain their potential contribution diabetes, where targets required address.
eurekaselect.com参考文章(83)
Min Liao, Cong Dai, Mengping Liu, Jiefeng Chen, Zuanguang Chen, Zhiyong Xie, Meicun Yao, Simultaneous determination of four furostanol glycosides in rat plasma by UPLC-MS/MS and its application to PK study after oral administration of Dioscorea nipponica extracts. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 117, pp. 372- 379 ,(2016) , 10.1016/J.JPBA.2015.09.021
Festus BC Okoye, Wamtinga Richard Sawadogo, Jandirk Sendker, Amal H Aly, Bettina Quandt, Victor Wray, Andreas Hensel, Charles O Esimone, Abdessamad Debbab, Marc Diederich, Peter Proksch, None, Flavonoid glycosides from Olax mannii: Structure elucidation and effect on the nuclear factor kappa B pathway. Journal of Ethnopharmacology. ,vol. 176, pp. 27- 34 ,(2015) , 10.1016/J.JEP.2015.10.019
D van Soolingen, P W Hermans, P E de Haas, D R Soll, J D van Embden, Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis. Journal of Clinical Microbiology. ,vol. 29, pp. 2578- 2586 ,(1991) , 10.1128/JCM.29.11.2578-2586.1991
Celia Bustos-Brito, Mariano Sánchez-Castellanos, Baldomero Esquivel, José S. Calderón, Fernando Calzada, Lilian Yépez-Mulia, Pedro Joseph-Nathan, Gabriel Cuevas, Leovigildo Quijano, ent-Kaurene Glycosides from Ageratina cylindrica. Journal of Natural Products. ,vol. 78, pp. 2580- 2587 ,(2015) , 10.1021/ACS.JNATPROD.5B00488
Bushra Jabeen, Naheed Riaz, Muhammad Saleem, Muhammad Akram Naveed, Muhammad Ashraf, Umber Alam, Hafiza Mehwish Rafiq, Rasool Bakhsh Tareen, Abdul Jabbar, Isolation of natural compounds from Phlomis stewartii showing α-glucosidase inhibitory activity. Phytochemistry. ,vol. 96, pp. 443- 448 ,(2013) , 10.1016/J.PHYTOCHEM.2013.09.015
Cui-Ting Luo, Huan-huan Zheng, Shuang-Shuang Mao, Mao-xun Yang, Cheng Luo, Heru Chen, Xanthones from Swertia mussotii and their α-glycosidase inhibitory activities. Planta Medica. ,vol. 80, pp. 201- 208 ,(2013) , 10.1055/S-0033-1360173
Hideto Kimura, Shota Tokuyama, Tomoe Ishihara, Satoshi Ogawa, Kazushige Yokota, Identification of new flavonol O-glycosides from indigo (Polygonum tinctorium Lour) leaves and their inhibitory activity against 3-hydroxy-3-methylglutaryl-CoA reductase Journal of Pharmaceutical and Biomedical Analysis. ,vol. 108, pp. 102- 112 ,(2015) , 10.1016/J.JPBA.2015.02.005
Anand Mehta, Nicole Zitzmann, Pauline M Rudd, Timothy M Block, Raymond A Dwek, α-Glucosidase inhibitors as potential broad based anti-viral agents FEBS Letters. ,vol. 430, pp. 17- 22 ,(1998) , 10.1016/S0014-5793(98)00525-0
Jing Hua, Jin Qi, Bo-Yang Yu, Iridoid and phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl. and their α-glucosidase inhibitory activities. Fitoterapia. ,vol. 93, pp. 67- 73 ,(2014) , 10.1016/J.FITOTE.2013.11.011
Valery M. Dembitsky, Astonishing diversity of natural surfactants: 5. Biologically active glycosides of aromatic metabolites. Lipids. ,vol. 40, pp. 869- 900 ,(2005) , 10.1007/S11745-005-1449-2