Interplay of LRRK2 with chaperone-mediated autophagy
作者： Samantha J Orenstein , Sheng-Han Kuo , Inmaculada Tasset , Esperanza Arias , Hiroshi Koga
DOI: 10.1038/NN.3350
关键词: Mutant 、 Autophagy 、 LRRK2 、 Transgene 、 Genetically modified mouse 、 Kinase 、 Chaperone-mediated autophagy 、 HEK 293 cells 、 Biology 、 Molecular biology
摘要: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. We found LRRK2 to be degraded in lysosomes by chaperone-mediated …
nature.com
core.ac.uk
elsevier.com
sci-hub.se 参考文章(55)
Roland G. W. Staal, Stephen Rayport, David Sulzer, Amperometric Detection of Dopamine Exocytosis from Synaptic Terminals CRC Press/Taylor & Francis. ,(2007)
Brian Storrie, Edward Amadden, Isolation of subcellular organelles. Methods in Enzymology. ,vol. 182, pp. 203- 225 ,(1990) , 10.1016/0076-6879(90)82018-W
Maria Grazia Spillantini, Marie Luise Schmidt, Virginia M.-Y. Lee, John Q. Trojanowski, Ross Jakes, Michel Goedert, α-Synuclein in Lewy bodies Nature. ,vol. 388, pp. 839- 840 ,(1997) , 10.1038/42166
H L Chiang, J F Dice, Peptide sequences that target proteins for enhanced degradation during serum withdrawal. Journal of Biological Chemistry. ,vol. 263, pp. 6797- 6805 ,(1988) , 10.1016/S0021-9258(18)68713-7
Leonidas Stefanis, Kristin E. Larsen, Hardy J. Rideout, David Sulzer, Lloyd A. Greene, Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death The Journal of Neuroscience. ,vol. 21, pp. 9549- 9560 ,(2001) , 10.1523/JNEUROSCI.21-24-09549.2001
A M Cuervo, S R Terlecky, J F Dice, E Knecht, Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes. Journal of Biological Chemistry. ,vol. 269, pp. 26374- 26380 ,(1994) , 10.1016/S0021-9258(18)47204-3
Ana Maria Cuervo, Chaperone-mediated autophagy: selectivity pays off Trends in Endocrinology and Metabolism. ,vol. 21, pp. 142- 150 ,(2010) , 10.1016/J.TEM.2009.10.003
A. M. Cuervo, J. F. Dice, A receptor for the selective uptake and degradation of proteins by lysosomes Science. ,vol. 273, pp. 501- 503 ,(1996) , 10.1126/SCIENCE.273.5274.501
Han Seok Ko, Rachel Bailey, Wanli W. Smith, Zhaohui Liu, Joo-Ho Shin, Yun-Il Lee, Yong-Jie Zhang, Haibing Jiang, Christopher A. Ross, Darren J. Moore, Cam Patterson, Leonard Petrucelli, Ted M. Dawson, Valina L. Dawson, CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 2897- 2902 ,(2009) , 10.1073/PNAS.0810123106
C.C. Lowry, N.H. Kraeft, F.A. Hughes, Blastomycosis of the lung The American Journal of Surgery. ,vol. 81, pp. 676- 679 ,(1951) , 10.1016/0002-9610(51)90161-4