Role of Trichloroethylene in Parkinson’s Disease

摘要: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, primarily affecting older adults. Given projected growth and aging trend of population, prevalence PD expected to double by year 2040, highlighting imperative need for a better understanding disease. It generally accepted that development idiopathic multifactorial, involving both genetic environmental factors; however, relatively little known about specific exposures. An association between TCE exposure increased risk has been suggested several case reports/clusters, recently, first epidemiologic study found significant six-fold associated with occupational exposure. Data from animal studies also support plausible mechanistic pathway, rodent models demonstrating TCE-induced neurotoxic effects similar those occurring in PD. ubiquitous, even modest could have enormous population-level neurological health implications.