Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation.

摘要: Recent excitement regarding immune clearance of intracellular microorganisms has focused on two systems that maintain cellular homeostasis. One system includes autophagy components mediate degradation pathogens in membrane-bound compartments, a process termed xenophagy. The second is driven by interferon-regulated GTPases promote rupture pathogen-containing vacuoles and microbial degradation. In the case xenophagy, pathogen sequestration compartmentalization suppress inflammation. contrast, interferon-driven events can lead to exposure pathogen-associated molecular patterns host cytosol with consequent inflammasome activation. Paradoxically, signals factors involved xenophagy also mobilize GTPases, which drive inflammatory response, indicating considerable cross-talk between these pathways. How responses are prioritized remains be understood. this review, we describe mechanisms rely machinery speculate how pathways engage each other balance elimination