Effects of dietary fish oil supplementation on platelet aggregability and platelet membrane fluidity in normolipemic subjects with and without high plasma Lp(a) concentrations.
作者： E. Malle , W. Sattler , E. Prenner , H.J. Leis , A. Hermetter
DOI: 10.1016/0021-9150(91)90081-D
关键词: Fish oil 、 Membrane fluidity 、 Endocrinology 、 Internal medicine 、 Platelet 、 Dietary fish oil 、 Biochemistry 、 Lipoprotein(a) 、 PLATELET MEMBRANE FLUIDITY 、 Chemistry 、 Pathophysiology 、 High plasma
摘要: Abstract The purpose of this study was to compare the relative effect n − 3 fatty acids on plasma lipids and platelet function in normolipemic subjects 8 with Lp(a) levels > 30 mg/dl 7 without detectable concentrations. Six weeks dietary supplementation (3.8 g EPA 2.9 DHA/d) significantly reduced ( P 2 generation from platelets decreased by approx. 45% Lp(a)-negative Lp(a)-positive donors after a 6 week intake. Four more restored pretreatment values TGs, aggregability TXB release. biophysical properties normolipemics high concentrations revealed similar structural order at 37°C using DPH, TMA-DPH, or 6-AS as fluorescent probes. Also temperature-dependent changes fluidity 17°C were observed preparations subjects. However, no subtle due nutrient intakes found all = 15, 19–28 yrs) fluorescence polarization technique. present data suggest vitro behaviour (which is considered risk for premature atherosclerosis) contrast certain hyperlipidemic stages.
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