Elevated plasma levels of soluble P-selectin in patients with acute myocardial infarction and unstable angina : An inverse link to lipoprotein(a)

作者: Dan-yan Xu , Shui-ping Zhao , Wei-ping Peng

DOI: 10.1016/S0167-5273(98)00075-8

关键词:

摘要: Abstract P-selectin in platelets and endothelial cells mediates adhesive interactions between platelet, leukocyte endothelium to form thrombi. The purpose of the present study was investigate plasma level soluble (sP-selectin) patients with coronary heart disease relationship sP-selectin concentration lipoprotein(a) [Lp(a)]. Levels Lp(a) were determined by enzyme-linked immunoabsorbent assay on taken from acute myocardial infarction (AMI), old (OMI), unstable angina (UA), stable (SA) controls. In AMI UA, levels (79.62±3.82 ng/ml, 43.75±2.97 respectively) significantly higher ( P r =−0.315

参考文章(30)
R. N. Poston, J. L. McGregor, P. R. Taylor, R. R. Johnson-Tidey, Increase in the adhesion molecule P-selectin in endothelium overlying atherosclerotic plaques. Coexpression with intercellular adhesion molecule-1. American Journal of Pathology. ,vol. 144, pp. 952- 961 ,(1994)
Ej Langford, A.S Brown, Aj de Belder, R.E.A Smith, J.F Martin, R.J Wainwright, M.R Thomas, M.W Radomski, S Moncada, Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty The Lancet. ,vol. 344, pp. 1458- 1460 ,(1994) , 10.1016/S0140-6736(94)90287-9
L M Buja, J T Willerson, Role of inflammation in coronary plaque disruption. Circulation. ,vol. 89, pp. 503- 505 ,(1994) , 10.1161/01.CIR.89.1.503
D E Lorant, M K Topham, R E Whatley, R P McEver, T M McIntyre, S M Prescott, G A Zimmerman, Inflammatory roles of P-selectin. Journal of Clinical Investigation. ,vol. 92, pp. 559- 570 ,(1993) , 10.1172/JCI116623
Marek Naruszewicz, Elizabeth Selinger, Jean Davignon, Oxidative modification of lipoprotein(a) and the effect of β-carotene Metabolism-clinical and Experimental. ,vol. 41, pp. 1215- 1224 ,(1992) , 10.1016/0026-0495(92)90012-Y
R P McEver, J H Beckstead, K L Moore, L Marshall-Carlson, D F Bainton, GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. Journal of Clinical Investigation. ,vol. 84, pp. 92- 99 ,(1989) , 10.1172/JCI114175
Katherine A. Hajjar, Dov Gavishi, Jan L. Breslow, Ralph L. Nachman, Lipoprotein(a) modulation of endothelial cell surface fibrinolysis and its potential role in atherosclerosis. Nature. ,vol. 339, pp. 303- 305 ,(1989) , 10.1038/339303A0
Hisao Ikeda, Yoshinori Takajo, Kazuya Ichiki, Takafumi Ueno, Sanae Maki, Takehiko Noda, Kenzo Sugi, Tsutomu Imaizumi, Increased soluble form of P-selectin in patients with unstable angina. Circulation. ,vol. 92, pp. 1693- 1696 ,(1995) , 10.1161/01.CIR.92.7.1693
Anna Gries, Maria Gries, Helmut Wurm, Thomas Kenner, Martin Ijsseldijk, Jan J. Sixma, Gert M. Kostner, Lipoprotein(a) Inhibits Collagen-Induced Aggregation of Thrombocytes Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 16, pp. 648- 655 ,(1996) , 10.1161/01.ATV.16.5.648