Methods of treating hemophilia or von willebrand disease with p-selectin

作者: Daqing W. Hartwell , Patrick Andre , Denisa D. Wagner , Ingrid Hrachovinova

DOI:

关键词: ImmunologyClinical evaluationClinical trialBioinformaticsHemorrhagic disorderHemostasisVon Willebrand diseaseDiagnostic evaluationHemostatic DisordersMedicineP-selectin

摘要: The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the relates to methods for identification and use modulators activity also compositions diagnosis treatment hemostatic disorders, including, but not limited to, hemorrhagic disorders thrombotic disorders. describes diagnostic evaluation prognosis various conditions, subjects exhibiting predisposition such conditions. In addition, provides monitoring patients undergoing clinical or vascular efficacy compounds in trials.

参考文章(36)
Basili S, Vieri M, Alessandri C, Ferroni P, Cordova C, Martini F, Gazzaniga Pp, Labbadia G, Soluble P-selectin as a marker of platelet hyperactivity in patients with chronic obstructive pulmonary disease. Journal of Investigative Medicine. ,vol. 48, pp. 21- 27 ,(2000)
James C. Paulson, Michael Nunn, Margaret J. Polley, Carl Perez, Robert Bayer, Mary M. Bendig, Robert W. Chesnut, Jose W. Saldanha, Michael Kriegler, S. Tarran Jones, Method for detecting the presence of P-selectin ,(1997)
Andrew D Blann, Gregory Y H Lip, D Gareth Beevers, Charles N McCollum, Soluble P-selectin in atherosclerosis: a comparison with endothelial cell and platelet markers. Thrombosis and Haemostasis. ,vol. 77, pp. 1077- 1080 ,(1997) , 10.1055/S-0038-1656115
Gaëtan Berger, Daqing W. Hartwell, Denisa D. Wagner, P-Selectin and Platelet Clearance Blood. ,vol. 92, pp. 4446- 4452 ,(1998) , 10.1182/BLOOD.V92.11.4446
A Weller, S Isenmann, D Vestweber, Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha. Journal of Biological Chemistry. ,vol. 267, pp. 15176- 15183 ,(1992) , 10.1016/S0021-9258(18)42162-X
İbrahim C. Haznedaroglu, Yahya Büyükaşık, Ali Koşar, Osman İ. Özcebe, Şerafettin Kirazlı, Semra Dündar, Selectins and IL-6 during the clinical course of idiopathic thrombocytopenic purpura. Acta Haematologica. ,vol. 101, pp. 16- 20 ,(1999) , 10.1159/000040915
J Pan, R.P. McEver, Characterization of the promoter for the human P-selectin gene. Journal of Biological Chemistry. ,vol. 268, pp. 22600- 22608 ,(1993) , 10.1016/S0021-9258(18)41571-2