STAT5 is a potent negative regulator of TFH cell differentiation
作者： Robert J. Johnston , Youn Soo Choi , Jeffrey A. Diamond , Jessica A. Yang , Shane Crotty
DOI: 10.1084/JEM.20111174
关键词: Priming (immunology) 、 T cell 、 Cell biology 、 Interleukin 2 、 BCL6 、 Biology 、 Signal transduction 、 Cellular differentiation 、 Germinal center 、 Molecular biology 、 T follicular helper cell differentiation
摘要: … In this study, we show that STAT5 inhibits T FH cell differentiation and function. … that STAT5 was a physiological inhibitor of T FH cell differentiation and consequently that a lack of STAT5 …
rupress.org
jem.org
ufjf.br 参考文章(52)
Yi-Ling Hu, Daniela P. Metz, James Chung, Gerald Siu, Ming Zhang, B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. Journal of Immunology. ,vol. 182, pp. 1421- 1428 ,(2009) , 10.4049/JIMMUNOL.182.3.1421
Hirohito Ichii, Akemi Sakamoto, Yoshikazu Kuroda, Takeshi Tokuhisa, Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8 + T Cells Journal of Immunology. ,vol. 173, pp. 883- 891 ,(2004) , 10.4049/JIMMUNOL.173.2.883
Hisaya Akiba, Kazuyoshi Takeda, Yuko Kojima, Yoshihiko Usui, Norihiro Harada, Tomohide Yamazaki, Juan Ma, Katsunari Tezuka, Hideo Yagita, Ko Okumura, The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo Journal of Immunology. ,vol. 175, pp. 2340- 2348 ,(2005) , 10.4049/JIMMUNOL.175.4.2340
Isharat Yusuf, Robin Kageyama, Laurel Monticelli, Robert J. Johnston, Daniel DiToro, Kyle Hansen, Burton Barnett, Shane Crotty, Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). Journal of Immunology. ,vol. 185, pp. 190- 202 ,(2010) , 10.4049/JIMMUNOL.0903505
Matthew A. Burchill, Jianying Yang, Christine Vogtenhuber, Bruce R. Blazar, Michael A. Farrar, IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells Journal of Immunology. ,vol. 178, pp. 280- 290 ,(2007) , 10.4049/JIMMUNOL.178.1.280
Nicole M. Haynes, Christopher D. C. Allen, Robin Lesley, K. Mark Ansel, Nigel Killeen, Jason G. Cyster, Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation Journal of Immunology. ,vol. 179, pp. 5099- 5108 ,(2007) , 10.4049/JIMMUNOL.179.8.5099
Sema Kurtulus, Sara Wojciechowski, Allyson Sholl, Kasper Hoebe, Suzanne C. Morris, Fred D. Finkelman, H. Leighton Grimes, David A. Hildeman, Pulak Tripathi, STAT5 Is Critical To Maintain Effector CD8+ T Cell Responses Journal of Immunology. ,vol. 185, pp. 2116- 2124 ,(2010) , 10.4049/JIMMUNOL.1000842
Mayumi Onishi, Tetsuya Nosaka, Kazuhide Misawa, Alice L.-F. Mui, Daniel Gorman, Martin McMahon, Atsushi Miyajima, Toshio Kitamura, Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation Molecular and Cellular Biology. ,vol. 18, pp. 3871- 3879 ,(1998) , 10.1128/MCB.18.7.3871
Amanda C. Poholek, Kyle Hansen, Sairy G. Hernandez, Danelle Eto, Anmol Chandele, Jason S. Weinstein, Xuemei Dong, Jared M. Odegard, Susan M. Kaech, Alexander L. Dent, Shane Crotty, Joe Craft, In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development Journal of Immunology. ,vol. 185, pp. 313- 326 ,(2010) , 10.4049/JIMMUNOL.0904023
Hyokjoon Kwon, Danielle Thierry-Mieg, Jean Thierry-Mieg, Hyoung-Pyo Kim, Jangsuk Oh, Chainarong Tunyaplin, Sebastian Carotta, Colleen E. Donovan, Matthew L. Goldman, Prafullakumar Tailor, Keiko Ozato, David E. Levy, Stephen L. Nutt, Kathryn Calame, Warren J. Leonard, Analysis of Interleukin-21-Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors Immunity. ,vol. 31, pp. 941- 952 ,(2009) , 10.1016/J.IMMUNI.2009.10.008