Convergent C-glycolipid synthesis via the Ramberg-Bäcklund reaction: active antiproliferative glycolipids.
作者： Guangli Yang , Richard W. Franck , Hoe-Sup Byun , Robert Bittman , Pranati Samadder
DOI: 10.1021/OL991211F
关键词: Glycolipid 、 Stereoselectivity 、 Glycolipid synthesis 、 Anomer 、 Stereochemistry 、 Chemistry 、 Ramberg–Bäcklund reaction 、 Ionic bonding
摘要: [formula: see text] A novel methodology has been developed, employing the Ramberg-Backlund rearrangement and ionic hydrogenation to synthesize C-glycosides with high stereoselectivity at anomeric center. The C-glycolipid 14b exhibits antiproliferative properties similar those of O-glycoside analogue 14a.
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