L-proline and citric acid co-crystals of (2s, 3r, 4r, 5s, 6r )- 2- (3- ((5- (4-fluorophenyl)thiophen-2-yl) methyl) -4-methylphenyl)-6- (hydroxymethyl)tetrahydro-2h-pyran-3,4,5-triol
作者： Edwin A. Collier , Minh Nguyen
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摘要: The present invention is directed to L-proline and citric acid co-crystals of (2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4- methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, pharmaceutical compositions containing said their use in the treatment glucose-related disorders such as Type 2 diabetes mellitus Syndrome X.
google.co.in 参考文章(251)
Ralph A. DeFronzo, Ele Ferrannini, Leif Groop, Robert R. Henry, William H. Herman, Jens Juul Holst, Frank B. Hu, C. Ronald Kahn, Itamar Raz, Gerald I. Shulman, Donald C. Simonson, Marcia A. Testa, Ram Weiss, Type 2 diabetes mellitus. Nature Reviews Disease Primers. ,vol. 1, pp. 15019- ,(2015) , 10.1038/NRDP.2015.19
Kenneth Emancipator, Laboratory Diagnosis and Monitoring of Diabetes Mellitus American Journal of Clinical Pathology. ,vol. 112, pp. 665- 674 ,(1999) , 10.1093/AJCP/112.5.665
Paul Reider, Sandor Karady, Ross Miller, Piperazine carboxamide intermediates of HIV protease inhibitors and processes for their preparation ,(2002)
Barbara A. Ramlo-Halsted, Steven V. Edelman, THE NATURAL HISTORY OF TYPE 2 DIABETES: Implications for Clinical Practice Primary Care. ,vol. 26, pp. 771- 790 ,(1999) , 10.1016/S0095-4543(05)70130-5
Masayuki Isaji, Sodium-glucose cotransporter inhibitors for diabetes. Current opinion in investigational drugs. ,vol. 8, pp. 285- 292 ,(2007)
Brett C Bookser, 2-Benzyloxymethyl-5-(tributylstannyl)tetrazole. A reagent for the preparation of 5-aryl- and 5-heteroaryl-1H-tetrazoles via the Stille reaction† Tetrahedron Letters. ,vol. 41, pp. 2805- 2809 ,(2000) , 10.1016/S0040-4039(00)00268-9
Kazuya Kitagawa, Atsushi Inoue, Hiroshi Shinokubo, Koichiro Oshima, Halogen–Magnesium Exchange via Trialkylmagnesates for the Preparation of Aryl‐ and Alkenylmagnesium Reagents Angewandte Chemie. ,vol. 39, pp. 2481- 2483 ,(2000) , 10.1002/1521-3773(20000717)39:14<2481::AID-ANIE2481>3.0.CO;2-J
Nicholas A. Meanwell, Sing Yuen Sit, Jinnian Gao, Henry S. Wong, Qi Gao, Denis R. St. Laurent, Neelakantan Balasubramanian, REGIOSPECIFIC FUNCTIONALIZATION OF 1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE AND STRUCTURALLY RELATED CYCLIC UREA DERIVATIVES Journal of Organic Chemistry. ,vol. 60, pp. 1565- 1582 ,(1995) , 10.1021/JO00111A014
Guangli Yang, Richard W. Franck, Hoe-Sup Byun, Robert Bittman, Pranati Samadder, Gilbert Arthur, Convergent C-glycolipid synthesis via the Ramberg-Bäcklund reaction: active antiproliferative glycolipids. Organic Letters. ,vol. 1, pp. 2149- 2151 ,(1999) , 10.1021/OL991211F
George A. Patani, Edmond J. LaVoie, Bioisosterism: A Rational Approach in Drug Design. Chemical Reviews. ,vol. 96, pp. 3147- 3176 ,(1996) , 10.1021/CR950066Q