2-Benzyloxymethyl-5-(tributylstannyl)tetrazole. A reagent for the preparation of 5-aryl- and 5-heteroaryl-1H-tetrazoles via the Stille reaction†
作者： Brett C Bookser
DOI: 10.1016/S0040-4039(00)00268-9
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摘要: Abstract 2-Benzyloxymethyl-5-(tributylstannyl)tetrazole (2) is a useful reagent for the conversion of aryl- and heteroaryl-halides (bromides iodides) to 5-aryl- 5-heteroaryl-1H-tetrazoles. The entails copper(I) iodide co-catalyzed Stille palladium-catalyzed cross-coupling reaction N-benzyloxymethyl deprotection step. Coupling was possible with electron neutral poor substrates in yields ranging from 35–93%.
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