Expression vectors for large-scale production of rAAV in the baculovirus/Sf9 system
作者： Maranga Luis , Slack Jeffrey Morley
DOI:
关键词: Cell biology 、 Biology 、 Production (economics) 、 Sf21 、 Spodoptera 、 Sf9 、 Expression vector 、 Gene 、 Virus 、 Recombinant DNA
摘要: The present disclosure describes methods and systems for use in the production of adeno-associated virus (AAV) particles, including recombinant (rAAV) particles. In certain embodiments, process system Baculoviral Expression Vectors (BEVs) AAV Spodoptera frugiperda insect cells (such as Sf9 or Sf21) viral cells. BEVs which lacks a portion an entirety v-cath gene includes mutationally inactivated version gene.
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