Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes.

摘要: MacKenzie KE, Wiltshire EJ, Pen˜a AS, Gent R, Hirte C, Piotto L,Couper JJ. Hs–CRP is associated with weight, BMI, and female sex butnot endothelial function in children type 1 diabetes.Pediatric Diabetes 2009: 10: 44–51.Background: Atherosclerosis an inflammatory process, high-sensitivity C-reactive protein (Hs-CRP), a marker of inflammation,predicts cardiovascular events adults. Vascular smoothmuscle dysfunction, measurable precursors atherosclerosis, begin inchildhood. Therefore, we sought to determine if Hs-CRP associatedwith vascular smooth muscle dysfunction withtype diabetes mellitus (T1DM) healthy control subjects.Methods: assessed by flow-mediateddilatation (FMD) glyceryl-trinitrate (GTN)-induced dilatation were measured 121 subjects withT1DM aged 14.1 (2.9) yr, whom 31 also studied at 4 8 wk,and 33 controls 14.2 (3.6) yr.Results: did not differ between T1DM andhealthy, age-matched controls. In both T1DM,Hs-CRP relate FMD or GTN baseline intervals over8 wk T1DM. change over time. T1DM, but nothealthy controls, related body mass index (BMI) z-score(r ¼ 0.47, p , 0.001), weight z-score (r 0.41, femalesex (p 0.008).Conclusions: early inchildren However, adolescents was higher BMI,suggesting that these groups may be greater risk.Maintenance BMI important the prevention ofvascular disease