Few associations between high-sensitivity C-reactive protein and environmental factors in 4.5-year-old children.

摘要: To cite this article: Mustonen K, Keski-Nisula L, Vaarala O, Pfefferle PI, Renz H, Riedler J, Dalphin J-C, Buechele G, Lauener R, Braun-Fahrlander C, von Mutius E, Pekkanen J and the PASTURE Study Group. Few associations between high-sensitivity C-reactive protein environmental factors in 4.5-year-old children. Pediatr Allergy Immunol 2012: 00. ABSTRACT: Background: Low-grade inflammation early childhood might protect from allergic diseases later life. Our aim was to examine effects of different on low-grade measured with serum (hsCRP) at age 4.5 years. Methods: The CRP values (n = 653) serum-specific IgE concentrations were children rural areas five European countries (Austria, Finland, France, Germany, Switzerland). Children belonged prospective multi-center birth cohort. Data current farming environment domestic animal exposure collected by questionnaires. Results: Females as well obese or very years had higher hsCRP than males (aOR 1.84 95% CI 1.27-2.66) healthy weight 4.47 1.94-10.31), respectively. Levels lowest summer. detected farm atopic sensitization. However, there evidence low levels (below detection limit) who increased prevalence sensitization inhaled seasonal allergens. Among non-sensitized children, spending time stables associated reduced (15 min-10 h aOR 0.40 0.16-0.96