Mitochondrial remodeling in cancer metabolism and survival: potential for new therapies.
作者： Inês A. Barbosa , Nuno G. Machado , Andrew J. Skildum , Patricia M. Scott , Paulo J. Oliveira
DOI: 10.1016/J.BBCAN.2012.04.005
关键词: Mitochondrial DNA 、 Cancer cell 、 Voltage-dependent anion channel 、 Carcinogenesis 、 Programmed cell death 、 PI3K/AKT/mTOR pathway 、 Cancer 、 Cancer research 、 Biology 、 Bioinformatics 、 Mitochondrion
摘要: Mitochondria are semi-autonomous organelles that play essential roles in cellular metabolism and programmed cell death pathways. Genomic, functional structural mitochondrial alterations have been associated with cancer. Some of those may provide a selective advantage to cells, allowing them survive grow under stresses created by oncogenesis. Due the specific occur cancer mitochondria, these promising targets for therapy. The development drugs specifically target metabolic tumor cells has become matter interest recent years, several molecules undergoing clinical trials. This review focuses on most relevant found their contribution progression survival, potential usefulness stratification
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