The effect of vitamin E or selenium on the oxidant-antioxidant balance in rats.

摘要: Vitamin E and selenium are two components which contribute to the antioxidant potential of plasma tissues. In present study we aimed define type tissue toxicity deriving from chronic deficiency either vitamin or evaluate reliability peripheral markers in these conditions. We studied rats fed a selenium-deficient diet for 3 7 months selenium-supplemented diet. The effectiveness dietary treatment was confirmed by measuring plasma. Heart kidney malondialdehyde (MDA), typical product lipid peroxidation, significantly increased after 3-month both E- rats. iron-binding capacity plasma, an activity ascribed transferrin, reduced animals. red cells globular resistance (resistance osmotic haemolysis) low selenium-deficient, but high Glutathione peroxidase also Platelet count did not differ controls any three conditions studied. MDA formation induced arachidonic acid raised and, particularly, E-deficient groups. This can be regarded as marker defence at level.