Cutaneous reactions to aspirin and nonsteroidal antiinflammatory drugs.

摘要: Soon after the introduction of aspirin for treatment pain, fever, and inflammation more than a century ago, clinicians were challenged by frequent observation ASA-triggered allergic pseudoallergic reactions occurring in skin. This problem was further enhanced development number other analgesic antiinflammatory drugs that, having different chemical structures, cross-reacted with acetilsalycilic acid many patients. paper reviews information presently available management individuals who develop urticaria angioedema when exposed to that inhibit cyclooxygenase isoenzymes. The immune nonimmunologic mechanisms leading pathogenesis such reactions, their prevalence selected groups population, clinical picture, useful diagnostic approaches are described, current guidelines used our institutions orientation patients, taking advantage recent various new selective NSAIDS preferentially COX-2 enzyme, proposed.