Enhancing Effect of Vasopressin on the Hyperglycemic Response to Carotid Body Chemoreceptor Stimulation

摘要: Glucose homeostasis, a fundamental process for life, is controlled at multiple levels. sensitive receptors in the brain, portal vein, liver, pancreas and carotid bodies (Alvarez-Buylla Roces de Alvarez-Buylla, 1994) provide afferent information to central nervous system (CNS) about glucose concentration different regions of body. In CNS, this input integrated by hypothalamus nucleus tractus solitarius (NTS) (Adachi et al., 1995). Additionally, there evidence that body (CBR) are also changes blood (Alvarez- Buylla 1994; Lopez-Barneo 2001) impulses from these induce reflex response on levels: 1) enhancing production 2 promoting retention brain. Carotid play an important role insulin-induced counterregulatory mild hypoglycemia (Koyama 2000). The efferent pathway reflexes not fully understood, but previous experiments identify neurohypophysis adrenal glands as necessary hyperglycemic initiated NaCN stimulation, suggest effects two CBR humoral 1997). This supported finding neurohypophyseal hormone arginine-vasopressin (AVP) has modulatory metabolism during stress, increase vasopressin plasma levels observed after perfusion sinus with deoxygenated blood, method similar stimulation (Share Levy, 1966). addition, hypophysectomy leads cortical atrophy (Wurtman 1968). We have previously hypothesized pituitary AVP may be involved stimulation. paper we extend study regulating level NTS (Yarkov 2001), peptide facilitate elicited show can directly trigger obtained interact located NTS, cells stimulate secretion epinephrine (E) glucagon.