Morphine directly inhibits nociceptors in inflamed skin.

作者: Heather N. Wenk , Jill-Desiree Brederson , Christopher N. Honda

DOI: 10.1152/JN.00394.2005

关键词: OpioidReceptorInflammationMorphinePharmacologyNociceptorDose–response relationshipSignal transductionMedicinePeripheral

摘要: Peripherally delivered opiates attenuate mechanical and thermal hyperalgesia in experimental models of inflammation, suggesting that activation peripheral opioid receptors decreases the excitabi...

参考文章(101)
Allan Basbaum, Opioids in Pain Control Nature Medicine. ,vol. 5, pp. 371- 372 ,(1999) , 10.1038/7359
M. Kress, M. Koltzenburg, P. W. Reeh, H. O. Handwerker, Responsiveness and functional attributes of electrically localized terminals of cutaneous C-fibers in vivo and in vitro Journal of Neurophysiology. ,vol. 68, pp. 581- 595 ,(1992) , 10.1152/JN.1992.68.2.581
Christoph Stein, Peter J. Cabot, Michael Schafer, Opioids in Pain Control: Peripheral Opioid Analgesia: Mechanisms and Clinical Implications Cambridge University Press. pp. 96- 108 ,(1998) , 10.1017/CBO9780511575068.007
Fernand Anton, Peter-Werner Reeh, Hermann-Otto Handwerker, Laurence Kocher, Nociceptor functions in intact skin and in neurogenic or non-neurogenic inflammation. Acta Physiologica Hungarica. ,vol. 69, pp. 333- ,(1987)
S. C. Ahlgren, D. M. White, J. D. Levine, Increased responsiveness of sensory neurons in the saphenous nerve of the streptozotocin-diabetic rat. Journal of Neurophysiology. ,vol. 68, pp. 2077- 2085 ,(1992) , 10.1152/JN.1992.68.6.2077
N H. Wenk, N M. Nannenga, N C. Honda, Effect of morphine sulphate eye drops on hyperalgesia in the rat cornea. Pain. ,vol. 105, pp. 455- 465 ,(2003) , 10.1016/S0304-3959(03)00260-4
U Arvidsson, RJ Dado, M Riedl, JH Lee, PY Law, HH Loh, R Elde, MW Wessendorf, delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin The Journal of Neuroscience. ,vol. 15, pp. 1215- 1235 ,(1995) , 10.1523/JNEUROSCI.15-02-01215.1995
U Arvidsson, M Riedl, S Chakrabarti, JH Lee, AH Nakano, RJ Dado, HH Loh, PY Law, MW Wessendorf, R Elde, Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord The Journal of Neuroscience. ,vol. 15, pp. 3328- 3341 ,(1995) , 10.1523/JNEUROSCI.15-05-03328.1995