Gastrointestinal Stromal Tumour (GIST): Diagnosis and Treatment

作者: Attila Kollàr

DOI: 10.1007/978-3-319-21683-6_31

关键词: Autonomic nervous systemIncidence (epidemiology)DiseaseInterstitial cell of CajalStromal cellPathologyGiSTGastrointestinal tractMesenchymal NeoplasmMedicine

摘要: Gastrointestinal stromal tumours (GIST) represent the most common mesenchymal neoplasm in gastrointestinal tract with an annual worldwide incidence of approximately 15 cases per million year. They are thought to arise from interstitial cells Cajal, which part autonomic nervous system intestine. The primary treatment goal early-stage disease is complete surgical resection, but recurrence and metastasization can be documented more than 40 % during follow-up.

参考文章(113)
Kazuya Akahoshi, Yorinobu Sumida, Noriaki Matsui, Masafumi Oya, Rie Akinaga, Masaru Kubokawa, Yasuaki Motomura, Kuniomi Honda, Masayuki Watanabe, Takashi Nagaie, Preoperative diagnosis of gastrointestinal stromal tumor by endoscopic ultrasound-guided fine needle aspiration World Journal of Gastroenterology. ,vol. 13, pp. 2077- 2082 ,(2007) , 10.3748/WJG.V13.I14.2077
Christin A. Knowlton, Luther W. Brady, Rebecca C. Heintzelman, Radiotherapy in the treatment of gastrointestinal stromal tumor Rare Tumors. ,vol. 3, pp. 35- ,(2011) , 10.4081/RT.2011.E35
Markku Miettinen, Jerzy Lasota, Gastrointestinal Stromal Tumors: Review on Morphology, Molecular Pathology, Prognosis, and Differential Diagnosis Archives of Pathology & Laboratory Medicine. ,vol. 130, pp. 1466- 1478 ,(2006) , 10.1043/1543-2165(2006)130[1466:GSTROM]2.0.CO;2
Donald Podoloff, Isis Gayed, Marcella Johnson, Revathy Iyer, Homer Macapinlac, Nancy Swanston, Thuan Vu, The Role of 18F-FDG PET in Staging and Early Prediction of Response to Therapy of Recurrent Gastrointestinal Stromal Tumors The Journal of Nuclear Medicine. ,vol. 45, pp. 17- 21 ,(2004)
Ihor Pidhorecky, Richard T. Cheney, William G. Kraybill, John F. Gibbs, Gastrointestinal stromal tumors: current diagnosis, biologic behavior, and management. Annals of Surgical Oncology. ,vol. 7, pp. 705- 712 ,(2000) , 10.1007/S10434-000-0705-6
Maria Debiec-Rychter, Jan Cools, Herlinde Dumez, Raf Sciot, Michel Stul, Nicole Mentens, Hilde Vranckx, Bartosz Wasag, Hans Prenen, Johannes Roesel, Anne Hagemeijer, Allan Van Oosterom, Peter Marynen, Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants Gastroenterology. ,vol. 128, pp. 270- 279 ,(2005) , 10.1053/J.GASTRO.2004.11.020
Antoine Italiano, Angela Cioffi, Paola Coco, Robert G. Maki, Patrick Schöffski, Piotr Rutkowski, Axel Le Cesne, Florence Duffaud, Antoine Adenis, Nicolas Isambert, Emmanuelle Bompas, Jean-Yves Blay, Paolo Casali, Mary Louise Keohan, Maud Toulmonde, Cristina R. Antonescu, Maria Debiec-Rychter, Jean-Michel Coindre, Binh Bui, Patterns of Care, Prognosis, and Survival in Patients with Metastatic Gastrointestinal Stromal Tumors (GIST) Refractory to First-Line Imatinib and Second-Line Sunitinib Annals of Surgical Oncology. ,vol. 19, pp. 1551- 1559 ,(2012) , 10.1245/S10434-011-2120-6
Markku Miettinen, John F Fetsch, Leslie H Sobin, Jerzy Lasota, Gastrointestinal stromal tumors in patients with neurofibromatosis 1: a clinicopathologic and molecular genetic study of 45 cases. The American Journal of Surgical Pathology. ,vol. 30, pp. 90- 96 ,(2006) , 10.1097/01.PAS.0000176433.81079.BD
Heikki Joensuu, Mikael Eriksson, Kirsten Sundby Hall, Jörg T. Hartmann, Daniel Pink, Jochen Schütte, Giuliano Ramadori, Peter Hohenberger, Justus Duyster, Salah-Eddin Al-Batran, Marcus Schlemmer, Sebastian Bauer, Eva Wardelmann, Maarit Sarlomo-Rikala, Bengt Nilsson, Harri Sihto, Odd R. Monge, Petri Bono, Raija Kallio, Aki Vehtari, Mika Leinonen, Thor Alvegård, Peter Reichardt, One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor JAMA. ,vol. 307, pp. 1265- 1272 ,(2012) , 10.1001/JAMA.2012.347
Hironobu Maeyama, Eiko Hidaka, Hiroyoshi Ota, Satoshi Minami, Masashi Kajiyama, Akira Kuraishi, Hiromitsu Mori, Yoshiaki Matsuda, Shuichi Wada, Harutsugu Sodeyama, Shinji Nakata, Nobuyuki Kawamura, Satoru Hata, Masahide Watanabe, Yoshihiro Iijima, Tsutomu Katsuyama, Familial gastrointestinal stromal tumor with hyperpigmentation : association with a germline mutation of the c-kit gene Gastroenterology. ,vol. 120, pp. 210- 215 ,(2001) , 10.1053/GAST.2001.20880