Mcl-1: a highly regulated cell death and survival controller
作者： Hsin-Fang Yang-Yen
DOI: 10.1007/S11373-005-9064-4
关键词: Cell biology 、 Programmed cell death 、 Regulated cell death 、 Molecular mechanism 、 Myeloid Cell Leukemia Sequence 1 Protein 、 Apoptosis Regulatory Proteins 、 Cell survival 、 Biology 、 Signal transduction 、 Apoptosis
摘要: Mcl-1 is one member of the Bcl-2 family that has a very short protein half-life. Since its identification in 1993, great number studies have implicated plays an important role various cell survival pathways. However, not until recently did molecular mechanism by which antagonizes apoptosis begun to be elucidated. rapidly degraded response death signals and immediately re-induced stimuli. These results indicate apical many regulatory programs.
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Cheun-Miin Leu, Chungming Chang, Cheng-po Hu, Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. Oncogene. ,vol. 19, pp. 1665- 1675 ,(2000) , 10.1038/SJ.ONC.1203452
Hsuan Liu, Hsien-Wei Peng, Yi-Sheng Cheng, Hanna S. Yuan, Hsin-Fang Yang-Yen, Stabilization and Enhancement of the Antiapoptotic Activity of Mcl-1 by TCTP Molecular and Cellular Biology. ,vol. 25, pp. 3117- 3126 ,(2005) , 10.1128/MCB.25.8.3117-3126.2005
Zhiqian Liu, Rose Oughtred, Simon S. Wing, Characterization of E3Histone, a Novel Testis Ubiquitin Protein Ligase Which Ubiquitinates Histones Molecular and Cellular Biology. ,vol. 25, pp. 2819- 2831 ,(2005) , 10.1128/MCB.25.7.2819-2831.2005
Terry Poulton, Yannick Gachet, Ulrich-Axel Bommer, Anthoula Lazaris-Karatzas, Melanie Lee, Sylvie Tournier, The growth-related, translationally controlled protein P23 has properties of a tubulin binding protein and associates transiently with microtubules during the cell cycle. Journal of Cell Science. ,vol. 112, pp. 1257- 1271 ,(1999) , 10.1242/JCS.112.8.1257
Deepak Nijhawan, Min Fang, Elie Traer, Qing Zhong, Wenhua Gao, Fenghe Du, Xiaodong Wang, Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation Genes & Development. ,vol. 17, pp. 1475- 1486 ,(2003) , 10.1101/GAD.1093903
Barbara Klocke, Susan Horning, Kevin Roth, Stanley J. Korsmeyer, Julie L. Rinkenberger, Mcl-1 deficiency results in peri-implantation embryonic lethality Genes & Development. ,vol. 14, pp. 23- 27 ,(2000) , 10.1101/GAD.14.1.23
Andrea Cuconati, Chandreyee Mukherjee, Denise Perez, Eileen White, DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells Genes & Development. ,vol. 17, pp. 2922- 2932 ,(2003) , 10.1101/GAD.1156903
Ju-Ming Wang, Jyh-Rong Chao, Wannhsin Chen, Min-Liang Kuo, Jeffrey J.-Y. Yen, Hsin-Fang Yang-Yen, The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Molecular and Cellular Biology. ,vol. 19, pp. 6195- 6206 ,(1999) , 10.1128/MCB.19.9.6195
Jyh-Rong Chao, Ju-Ming Wang, Shern-Fwu Lee, Hsien-Wei Peng, Yi-Hung Lin, Chiang-Hung Chou, Jian-Chiuan Li, Huei-Mei Huang, Chen-Kung Chou, Min-Liang Kuo, Jeffrey J.-Y. Yen, Hsin-Fang Yang-Yen, mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response Molecular and Cellular Biology. ,vol. 18, pp. 4883- 4898 ,(1998) , 10.1128/MCB.18.8.4883
Frederic R. Yarm, Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. Molecular and Cellular Biology. ,vol. 22, pp. 6209- 6221 ,(2002) , 10.1128/MCB.22.17.6209-6221.2002