Integration of metabolomics and proteomics in multiple sclerosis: From biomarkers discovery to personalized medicine

摘要: Personalized medicine is the science of individualized prevention and therapy. In last decade, advances in high-throughput approaches allowed development proteomic metabolomic studies evaluating association genetic phenotypic variability with disease sensitivity analgesic response. These considerations have more value case multiple sclerosis (MuS), a multifactorial high heterogeneity clinical course treatment this review, we reported updated about for research new candidate biomarkers MuS, difficulties their applications. We focused especially on description both "omics" that, once integrated, may synergically describe pathophysiology conditions. To prove assumption, rebuilt interaction between proteins metabolites described literature as potential pathway analysis these molecules was performed. The result such speculation demonstrated strong convergence results field, showing also poorness available tools incorporating approaches. conclusion, integration Metabolomics Proteomics allow complete characterization heterogeneous disease, providing further insights into personalized healthcare.