Cerebrospinal fluid analysis

摘要: The cerebrospinal fluid (CSF) is a bodily fluid, which both easily accessible and the most proximate to pathological alterations of multiple sclerosis (MS). Consequently, analysis this provides an important window into underpinnings disease. For example, for years, it has been known that CSF MS patients contains oligoclonal gamma immunoglobulins (IgG), are synthesized within central nervous system presumably relate immune dysfunction, characteristically found in MS. This insight lead introduction highly-effective anti-B-cell therapies field therapeutics. Moreover, presence IgG response CSF, although not specific MS, very sensitive finding and, as result, its can be quite helpful establishing diagnosis right clinical context. In addition, predictive value. Thus, without definite who have bands significantly more likely develop compared those such banding pattern. Other biological molecules also including neurofiliment, myelin basic protein (MBP), glial fibrillary acidic (GFAP), tau, neuronal cell adhesion molecule (NCAM), growth associated (GAP-43). However, value measuring these (and other) constituents diagnostic prognostic purposes following therapy still determined.