Formulas for the quantitation of intrathecal IgG production. Their validity in the presence of blood-brain barrier damage and their utility in multiple sclerosis.
作者： K. Blennow , P. Fredman , A. Wallin , C.G. Gottfries , H. Frey
DOI: 10.1016/0022-510X(94)90161-9
关键词:
摘要: Abstract There are several formulas for the quantitative determination of intrathecal IgG production: Reiber and Felgenhauer's formula (IgG(loc)), Extended index, Tourtellotte's (TOURT), Schuller Sagar's (SCHULL), Log Blennow co-workers' (IGGPROD). To evaluate utility these in presence blood-brain barrier (BBB) damage, we present results from a study serum cerebrospinal fluid (CSF) samples 125 healthy individuals, 18–88 years age; 1072 consecutive patients without oligoclonal bands (OCBs) CSF, 683 BBB damage (CSF/S: albumin ratio
elsevier.com
sci-hub.se 参考文章(22)
E. Schuller, H.J. Sagar, Local synthesis of CSF immunoglobulins ☆: A neuroimmunological classification Journal of the Neurological Sciences. ,vol. 51, pp. 361- 370 ,(1981) , 10.1016/0022-510X(81)90114-3
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh, “Mini-mental state” Journal of Psychiatric Research. ,vol. 12, pp. 189- 198 ,(1975) , 10.1016/0022-3956(75)90026-6
J O Jeppson, C B Laurell, B Franzén, Agarose gel electrophoresis. Clinical Chemistry. ,vol. 25, pp. 629- 638 ,(1979) , 10.1093/CLINCHEM/25.4.629
Karin Ganrot, Carl-Bertil Laurell, Measurement of IgG and Albumin Content of Cerebrospinal Fluid, and its Interpretation Clinical Chemistry. ,vol. 20, pp. 571- 573 ,(1974) , 10.1093/CLINCHEM/20.5.571
B. N. MCLEAN, R. W. LUXTON, E. J. THOMPSON, A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the Log IgG-Index. A comparison and diagnostic applications. Brain. ,vol. 113, pp. 1269- 1289 ,(1990) , 10.1093/BRAIN/113.5.1269
Robert W. Baumhefner, Quantitative Multiple Sclerosis Plaque Assessment With Magnetic Resonance Imaging Archives of Neurology. ,vol. 47, pp. 19- 26 ,(1990) , 10.1001/ARCHNEUR.1990.00530010027014
Sten Öhman, Pia Forsberg, Nina Nelson, Magnus Vrethem, An improved formula for the judgement of intrathecally produced IgG in the presence of blood brain barrier damage Clinica Chimica Acta. ,vol. 181, pp. 265- 272 ,(1989) , 10.1016/0009-8981(89)90232-5
Hansotto Reiber, Klaus Felgenhauer, Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system Clinica Chimica Acta. ,vol. 163, pp. 319- 328 ,(1987) , 10.1016/0009-8981(87)90250-6
Kaj Blennow, Pam Fredman, Anders Wallin, Carl-Gerhard Gottfries, Göran Långström, Lars Svennerholm, Protein analyses in cerebrospinal fluid. I. Influence of concentration gradients for proteins on cerebrospinal fluid/serum albumin ratio. European Neurology. ,vol. 33, pp. 126- 128 ,(1993) , 10.1159/000116918
Kaj Blennow, Pam Fredman, Anders Wallin, Carl-Gerhard Gottfries, Ingmar Skoog, Carsten Wikkelsö, Lars Svennerholm, Protein analysis in cerebrospinal fluid. III. Relation to blood-cerebrospinal fluid barrier function for formulas for quantitative determination of intrathecal IgG production. European Neurology. ,vol. 33, pp. 134- 142 ,(1993) , 10.1159/000116920