A study of immunoglobulin G in the cerebrospinal fluid of 1007 patients with suspected neurological disease using isoelectric focusing and the Log IgG-Index. A comparison and diagnostic applications.

摘要: Cerebrospinal fluid and serum immunoglobulin G from 1007 patients with suspected neurological disease were analysed by 2 methods: isoelectric focusing for the detection of oligoclonal banding, quantitative measurement IgG albumin formulation a Log IgG-Index. A comparison methods in local synthesis showed that not only gave much higher yield overall, 282 showing versus 225 IgG-Index, but also specificity, false positive rate 0% 3.5%. In addition, 163 (58%) Of studied, 206 had multiple sclerosis (MS), 95% clinically definite cases, 90% overall. The IgG-Index was 67% an overall 59% rate. Thus exceptions noted above, as defined is confined to demyelinating, inflammatory, infectious postinfectious disorders. Our results compare very favourably published sensitivities magnetic resonance imaging abnormalities sclerosis, better than those evoked potentials. Where both these investigations are readily available provides useful adjunct. For majority physicians neurologists who do have ready access imaging, excellent alternative. We would recommend it become standard cerebrospinal use data be abandoned routine purposes.