Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls.
作者： Insa Korten , Margot Liechti , Florian Singer , Gaudenz Hafen , Isabelle Rochat
DOI: 10.1016/J.JCF.2017.05.005
关键词: In patient 、 Airway 、 Medicine 、 Cystic fibrosis 、 Biomarker (medicine) 、 Immunology 、 Exhaled nitric oxide 、 Inflammation 、 Cystic fibrosis transmembrane conductance regulator
摘要: Exhaled nitric oxide (FENO) is a well-known, non-invasive airway biomarker. In patients with Cystic Fibrosis (CF) FENO decreased. To understand if reduced primary related to Transmembrane Conductance Regulator (CFTR) dysfunction or an epiphenomenon of chronic inflammation, we measured in 34 infants CF prior clinical symptoms and 68 healthy controls. was lower compared controls (p=0.0006) the effect more pronounced without residual CFTR function (p<0.0001). This suggests that early life, possibly associated underlying dysfunction.
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core.ac.uk参考文章(21)
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