Does haemophilia influence cancer-related mortality in HIV-negative patients?
作者： W. MIESBACH , E. SEIFRIED
DOI: 10.1111/J.1365-2516.2010.02364.X
关键词: Medicine 、 Liver disease 、 Virology 、 Coagulation Factor Deficiency 、 Haemophilia 、 Hepatitis C virus 、 Cancer 、 Hepatocellular carcinoma 、 Oncology 、 Epidemiology 、 Internal medicine 、 Population
摘要: Summary. Clinical investigations and animal studies suggest haemophilia specific effects on cancer-related mortality aside from virus induced malignancies. Analysis of results in the literature proposes that coagulation factor deficiency might inhibit cancer metastasis through decreased activation thrombin. On other hand, substitution increase rates. A review epidemiological was conducted to survey clinical data concerning always deal with virus-related malignancies caused by HIV and/or hepatitis C (HCV) infections. Therefore, analysis rates standardized ratios (SMR) under exclusion infection concomitant like non-Hodgkin-lymphomas HCV-related deaths liver disease hepatocellular carcinoma. The covers which report causes more than 8000 patients, including 2700 HIV-negative patients. Results show independent 8–16% deaths. corresponding SMRs supports hypothesis rates, unaffected or hepatoma, are when compared general population. Prospective collection regarding consumption as well severity negative patients is needed investigate interaction between cancer.
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