Cognitive ageing is premature among a community sample of optimally treated people living with HIV.

摘要: OBJECTIVES Evidence of premature cognitive ageing amongst people living with HIV (PLHIV) remains controversial due to previous research limitations including underpowered studies, samples suboptimal antiretroviral access, varying rate virological control, high AIDS, over-representation non-community samples, and inclusion inappropriate controls. The current study addresses these limitations, while also considering mental health non-HIV comorbidity burden determine whether PLHIV showed compared closely comparable HIV-negative METHODS This enrolled 254 [92% on therapy; 84% RNA < 50 copies/mL; 15% AIDS) 72 gay bisexual men [mean (SD) age = 49 (10.2) years] from a single primary care clinic in Sydney, Australia. Neurocognitive function was evaluated the Cogstate Computerized Battery (CCB) at baseline 6 months after. Linear mixed-effects (LME) models examined main interaction effects status chronological age CCB demographically uncorrected global neurocognitive z-score (GZS), adjusting for repeated testing, then sequentially disease markers, comorbidities. RESULTS interacted lower GZS (β = -0.43, P < 0.05). Higher level anxiety symptoms (β = -0.11, P < 0.01), historical AIDS (β = -0.12, P < 0.05) brain involvement were associated GZS. CONCLUSIONS We found robust medium-sized effect cognition community sample optimal care. Our supports routine screening among aged ≥ 50 years.