EVOLUZIONE DELLE METODICHE DI DEPURAZIONE EXTRA-CORPOREA: MARS (MOLECULAR ADSORBENT RECIRCULATING SYSTEM): TERAPIA SOSTITUTIVA DELLA FUNZIONE EPATICA E RENALE
作者： R. Marangoni
DOI:
关键词: Cholinesterase 、 Biochemistry 、 Dialysis 、 Closed loop 、 Cholestatic liver disease 、 Pharmacology 、 Alkaline phosphatase 、 Bilirubin 、 Albumin 、 Chemistry 、 Prothrombin.activity
摘要: replacement The Molecular Adsorbent Recirculating System (MARS) clears the blood from catabolites that either occur free in plasma water (through dialysis), such as uremic toxins and ammonia, or are bound by albumin, hepatic toxins. latter transferred albumin to circulating a closed loop where removed adsorption on resins (charcoal ion-exchange resin). efficacy of this extracorporeal purification method treatment acute acute-on-chronic liver failure (also associated with renal failure) has been demonstrated numerous studies. Fifty-one patients, 5 affected 46 acute-onchronic (8 them additional were treated MARS. results method, which effectively removes bilirubin, bile acids toxins, reduces concentration these molecules. It thereby improves patient’s clinical condition biochemical parameters including cholinesterase, alkaline phosphatase prothrombin activity, eliminating, addition, drug-refractory pruritus is very frequent symptom cholestatic disease. These agree those reported literature concerning MARS detoxifying function kidneys liver. (G Ital Nefrol 2007; 24: (Suppl. S38) S92-6) Conflict interest: None
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