Control of Mus81 nuclease during the cell cycle.

摘要: DNA replication and homologous recombination rely on the formation of branched structures that physically link chromosomes. Such DNA-based connections, which arise during S phase, are typically disengaged prior to entry into mitosis, in order ensure proper chromosome segregation. Exceptions can, however, occur: stress, or elevated levels damage, may cause cells enter mitosis with unfinished as well carrying intermediates, such Holliday junctions. Hence, equipped pathways recognize process structures, evolved mechanisms enhance their function when verge undergoing cell division. One these involves structure-selective endonuclease Mus81, is thought facilitate resolution intermediates. Mus81 known be enhanced upon M phase budding yeast model human cells. Based recent findings, we discuss here an updated control cycle. This article protected by copyright. All rights reserved.