Risk Factors for Post-TAVI Bleeding According to the VARC-2 Bleeding Definition and Effect of the Bleeding on Short-Term Mortality: A Meta-analysis

摘要: Abstract Background In this study we investigated the effect of post-transcatheter aortic valve implantation (TAVI) bleeding (per Valve Academic Research Consortium-2 [VARC-2] criteria) on 30-day postoperative mortality and examined correlation between pre- or intraoperative variables bleeding. Methods Multiple electronic literature databases were searched using predefined criteria, with defined per criteria. A total 10 eligible articles 3602 patients included in meta-analysis. Results The meta-analysis revealed that post-TAVI was associated a 323% increase (odds risk [OR]; 4.23, 95% confidence interval [CI], 2.80-6.40; P  = 0.005). Meta-regression showed potential modifiers like S ociety T horacic urgeons (STS) score, mortality, logistic Euro pean ystem for C ardiac O perative R isk E valuation (EuroSCORE), area, mean pressure gradient, left ventricular ejection fraction, preoperative hemoglobin platelet levels, design had no significant effects results Conclusions Post-TAVI bleeding, particular, major bleeding/life-threatening increased mortality. Transapical access factor. Preexisting AF independently correlated TAVI-associated likely because AF-related anticoagulation. Recognition importance determinants should lead to strategies improve outcomes.