Human milk oligosaccharide effects on intestinal function and inflammation after preterm birth in pigs.

摘要: Abstract Human milk oligosaccharides (HMOs) may mediate prebiotic and anti-inflammatory effects in newborns. This is particularly important for preterm infants who are highly susceptible to intestinal dysfunction necrotizing enterocolitis (NEC). We hypothesized that HMO supplementation of infant formula (IF) improves function, bacterial colonization NEC resistance immediately after birth, as tested a pig model. Mixtures HMOs were investigated epithelial cells pigs ( n =112) fed IF supplemented without (CON) or with mixture four (4-HMO) >25 (25-HMO, 5–10 g/L given 5 11 days). The 25-HMO blend decreased cell proliferation both blends lipopolysaccharide-induced interleukin-8 secretion IPEC-J2 cells, relative control P vs. CON 79%, =.2) but increased dehydration diarrhea IL10 , IL12 TGFβ TLR4; vitro gut gene expression fermentation pigs. However, the had limited on when IF. Longer-term exposure be required improve immature function formula-fed neonates.