A Signaling Pathway from the α5β1 and αvβ3 Integrins That Elevatesbcl-2 Transcription
作者： Michelle L. Matter , Erkki Ruoslahti
关键词: Cell adhesion 、 Cell biology 、 Signal transduction 、 Vitronectin 、 Activating transcription factor 2 、 Integrin 、 Fibronectin 、 Cancer research 、 Protein kinase A 、 Chemistry 、 Cell adhesion molecule
摘要: Integrin-mediated cell adhesion is necessary for the survival of many types, and loss causes apoptosis. We have previously shown that alpha5beta1 integrin supports on fibronectin increases Bcl-2 protein expression. Here we show bcl-2 transcription elevated in cells attach to through alpha(v)beta1 or vitronectin alpha(v)beta3 but not attaching integrin. expression protection from apoptosis under serum-free conditions correlated with transcription. This integrin-mediated regulation Shc- FAK-dependent, activation Ras by FAK required. Furthermore, mediates this up-regulation activating phosphatidylinositol 3-kinase-AKT pathway. Mitogen-activated kinase did appear be Therefore, our work characterizes pathway effect integrins survival.
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