摘要: The loss of integrin-mediated cell-matrix contact induces apoptosis ('anoikis') in certain cell types. Recently it has been shown that protein kinase signaling pathways control anoikis both positively and negatively. Focal adhesion kinase, when activated by integrins, can suppress anoikis. Phosphatidylinositol 3-kinase the AKT oncoprotein may mediate anoikis-suppressing effects focal kinase. Conversely, stress-activated kinase/Jun amino-terminal pathway promotes Latest results indicate caspase-mediated cleavage first component this latter pathway, MEKK-1, trigger activation In addition, integrins regulate bcl-2 expression levels, possibly adjusting threshold for
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