Evaluation of Periodontal Treatments Using Controlled‐Release Tetracycline Fibers: Microbiological Response

摘要: In a 12-month multi-center study of 116 adult periodontitis subjects, six putative periodontal pathogens were monitored by DNA probe methods in subset 31 subjects. Monitored species included Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn), Eikenella corrodens (Ec), Campylobacter rectus (Cr), and Actinobacillus actinomycetemcomitans (Aa) with an average detection limit 1.8 x 10(4) bacterial colony forming units/sample. The microbiological response to four treatments was studied, one treatment each quadrant; scaling root planing (S), tetracycline (TC) fiber (SF), single application TC (F) two serial applications (FF). Generally sites sampled quadrant, however, some quadrants only site selected. These evaluated at baseline; immediately following therapy; post-treatment 1, 3, 6, 12 months. conducted split-mouth design no maintenance therapy over period. At baseline, 70.8% had detectable Fn; 42.9% Pg; 63.5% Pi; 29.7% Ec; 28.3% Cr; 5.5% Aa. No significant differences seen baseline proportions these between centers. Numbers (with the exception Pg) exhibited triphasic temporal response: precipitous initial decrease rise 1- 3-month post-therapy period; spontaneous decline absence 3- period.(ABSTRACT TRUNCATED AT 250 WORDS)