Substance P modulates properties of bone marrow-derived mesenchymal stem cells
作者： Maria Jose Dubon , Yeji Byeon , Nunggum Jung , Youngsook Son , Ki-Sook Park
DOI: 10.1007/S13770-014-0012-0
关键词: Cell type 、 Immunology 、 Haematopoiesis 、 Mesenchymal stem cell 、 Stem cell 、 Wound healing 、 Chemistry 、 Stem cell transplantation for articular cartilage repair 、 Adipogenesis 、 Cell biology 、 Bone marrow
摘要: Bone marrow derived mesenchymal stem cells (MSCs) have self-renewal characteristics and are able to differentiate into various cell types. These can mobilize peripheral tissues in order participate important biological processes such as wound healing. They also regulate hematopoietic (HSCs) trafficking between the bone periphery through regulation of intercellular interactions expression cytokines, SDF-1. Previous studies demonstrated that substance P (SP) induces proliferation MSCs vitro mediates migration injury sites promote We found SP increases CFU-F total up-regulates osteogenic differentiation potential without affecting their adipogenic potential. mRNA levels SDF-1 N-cadherin marrow. Therefore, it is very likely modulates properties linked therapeutic role cells.
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