Adipose tissue browning in mice and humans

摘要: In the midst of an obesity epidemic, promotion brown adipose tissue (BAT) function and browning white (WAT) have emerged as promising therapeutic targets to increase energy expenditure counteract weight gain. Despite fact that thermogenic potential bone fide BAT in rodents is several orders magnitudes higher than fat containing brite/beige adipocytes, WAT represents a particularly intriguing concept humans given extreme amount excess obese individuals. addition, clear distinction between classic beige has been proposed mice does not exist humans. fact, studies human biopsies found controversial results suggesting both characteristics. Irrespective true ‘color’, accumulating evidence suggests induction adipocytes depots response specific stimuli, highlighting may occur both, These observations also emphasize great plasticity raise important questions about metabolic properties thermogenically active implications. We will first review cellular molecular aspects selected concepts identified mouse models with emphasis on neuronal factors, microbiome, immune cells hormones. summarize for including some experimental pharmacologic approaches.