A computer program for predicting protein antigenic determinants
作者： Thomas P. Hopp , Kenneth R. Woods
DOI: 10.1016/0161-5890(83)90029-9
关键词: Hepatitis b surface antigen 、 Basic language 、 Virology 、 Computational biology 、 Epitope 、 Peptide sequence 、 Biology 、 Antigen 、 Hemagglutinin (influenza) 、 A protein 、 Computer experience
摘要: A computerized method for predicting the locations of protein antigenic determinants is presented, which requires only amino acid sequence a protein, and no other information. This procedure has been used to predict major determinant hepatitis B surface antigen, as well sites on series test proteins known structure [Hopp & Woods (1981) Proc. natn. Acad. Sci. U.S.A. 78, 3824-3828.] The suitable use in smaller personal computers, written BASIC language, order make it available investigators with limited computer experience and/or resources. means locating multiple homologous demonstrated using influenza hemagglutinin an example.
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