Thymopoiesis independent of common lymphoid progenitors

作者: David Allman , Arivazhagan Sambandam , Sungjune Kim , Juli P. Miller , Antonio Pagan

DOI: 10.1038/NI878

关键词: Bone marrowGene rearrangementInterleukinCell biologyLineage (genetic)Ikaros Transcription FactorProgenitor cellImmunologyLymphoid progenitorsBiology

摘要: Early T lineage progenitors (ETPs) in the thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (BM). We compared thymic ETPs to BM CLPs in …

参考文章(39)
H.R. Rodewald, K. Kretzschmar, S. Takeda, C. Hohl, M. Dessing, Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization. The EMBO Journal. ,vol. 13, pp. 4229- 4240 ,(1994) , 10.1002/J.1460-2075.1994.TB06743.X
Kay L. Medina, Karla P. Garrett, Linda F. Thompson, Maria Isabel D. Rossi, Kimberly J. Payne, Paul W. Kincade, Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen Nature Immunology. ,vol. 2, pp. 718- 724 ,(2001) , 10.1038/90659
I Goldschneider, E Donskoy, Thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. A study in parabiotic mice. Journal of Immunology. ,vol. 148, pp. 1604- 1612 ,(1992)
P Marrack, J Kappler, W Born, J White, Rearrangement of IgH genes in normal thymocyte development. Journal of Immunology. ,vol. 140, pp. 3228- 3232 ,(1988)
Yoshimoto Katsura, Redefinition of lymphoid progenitors Nature Reviews Immunology. ,vol. 2, pp. 127- 132 ,(2002) , 10.1038/NRI721
Rachel S. Soloff, Deborah Dempsey, Lonnie Lybarger, Robert Chervenak, Tong Gang Wang, Transcription of the TCR-beta locus initiates in adult murine bone marrow. Journal of Immunology. ,vol. 154, pp. 3888- 3901 ,(1995)
D I Godfrey, A Zlotnik, T Suda, Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. Journal of Immunology. ,vol. 149, pp. 2281- 2285 ,(1992)
L. Puddington, U. von Freeden-Jeffry, L. Lefrançois, K. Laky, R. Murray, The Role of IL-7 in Thymic and Extrathymic Development of TCRγδ Cells Journal of Immunology. ,vol. 161, pp. 707- 713 ,(1998)
David Izon, Kristina Rudd, William DeMuth, Warren S. Pear, Cynthia Clendenin, R. Coleman Lindsley, David Allman, A Common Pathway for Dendritic Cell and Early B Cell Development Journal of Immunology. ,vol. 167, pp. 1387- 1392 ,(2001) , 10.4049/JIMMUNOL.167.3.1387
Motonari Kondo, David C. Scherer, Toshihiro Miyamoto, Angela G. King, Koichi Akashi, Kazuo Sugamura, Irving L. Weissman, Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines Nature. ,vol. 407, pp. 383- 386 ,(2000) , 10.1038/35030112