Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.
作者： Patrick R. Verhoest , Caroline Proulx-Lafrance , Michael Corman , Lois Chenard , Christopher J. Helal
DOI: 10.1021/JM9015334
关键词: Biochemistry 、 In vivo 、 Phosphoric Diester Hydrolases 、 Computational biology 、 Chemistry 、 Penetrant (biochemical)
摘要: By use of chemical enablement and prospective design, a novel series selective, brain penetrant PDE9A inhibitors have been identified that are capable producing in vivo elevations cGMP.
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rcsb.org参考文章(20)
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