Cutaneous nerve terminal degeneration in painful mononeuropathy.
作者： Yu-Wen Lin , To-Jung Tseng , Whei-Min Lin , Sung-Tsang Hsieh
关键词: Anatomy 、 Mononeuropathy 、 Wallerian degeneration 、 Cutaneous innervation 、 Langerhans cell 、 Cutaneous nerve 、 Nociception 、 Sciatic nerve 、 Pathology 、 Medicine 、 Neuropathic pain
摘要: Nociceptive nerves innervate the skin and play an important role in generation of neuropathic pain. However, it remains elusive whether how nociceptive nerve terminals degenerate pain conditions. To address this issue, we investigated cutaneous innervation a model painful mononeuropathy, chronic constriction injury (CCI). The hind paws rats were immunocytochemically stained with pan-axonal marker, protein gene product 9.5 (PGP 9.5). Within 2 days after CCI, exhibited thermal hyperalgesia, there was partial depletion epidermal nerves. extent reduction CCI variable density 3.65 ± 1.97 fibers/mm (compared to 15.39 1.58 on control side, P < 0.02). There mild but concomitant increase PGP (+) Langerhans cells epidermis (10.19 1.99 vs 7.75 1.36 cells/mm, 0.05). In denervated by tight ligation sciatic nerve, completely depleted (0 fibers/mmvs 12.26 1.44 0.001). Animals anesthesia. These findings suggest that is partially correlated development
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