Cellular Senescence in the Kidney
作者： Marie-Helena Docherty , Eoin D. O’Sullivan , Joseph V. Bonventre , David A. Ferenbach
关键词: Renal fibrosis 、 Organ dysfunction 、 Bioinformatics 、 Fibrosis 、 Kidney 、 Senescence 、 Kidney development 、 Homeostasis 、 Kidney disease 、 Medicine
摘要: Senescent cells have undergone permanent growth arrest, adopt an altered secretory phenotype, and accumulate in the kidney other organs with ageing injury. Senescence has diverse physiologic roles experimental studies support its importance nephrogenesis, successful tissue repair, opposing malignant transformation. However, recent murine shown that depletion of chronically senescent extends healthy lifespan delays age-associated disease-implicating senescence senescence-associated phenotype as drivers organ dysfunction. Great interest is therefore focused on manipulation a novel therapeutic target disease. In this review, we examine current knowledge areas ongoing uncertainty regarding human models. We summarize evidence supporting role normal development homeostasis but also senescence-induced maladaptive renal fibrosis, transplant failure. Recent using cell therapies to treat disease are discussed, explore unanswered questions for future research.
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