Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice.

摘要: Increased levels of particulate air pollution are associated with increased respiratory and cardiovascular mortality morbidity. Some epidemiologic toxicologic research suggests ultrafine particles (UFPs) ( SootL ≥ SootH > Printex90 PrintexG DEP. Relating the inflammatory effects to particle characteristics—organic content, primary size, or specific surface area—demonstrates most obvious dose response for area. Our study that area measurement developed by Brunauer, Emmett, Teller is a valuable reference unit assessment causative health carbonaceous UFPs. Additionally, we demonstrated existence threshold at an instilled approximately 20 cm2, below which no acute proinflammatory responses could be detected in mice.