Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo
作者： Leonard Moise , Chang Song , William D. Martin , Ryan Tassone , Anne S. De Groot
DOI: 10.1016/J.CLIM.2011.11.010
关键词: Immunology 、 T cell 、 Deimmunization 、 Biology 、 Epitope 、 Antibody 、 Recombinant DNA 、 HLA-DR 、 Immunogenicity 、 Virology 、 Human leukocyte antigen
摘要: … In the current study, we have confirmed and extended these studies to humanized HLA-DR transgenic mice, using state-of-the art immunoinformatic tools to select and de-immunize the …
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