Green, efficient and large-scale synthesis of benzimidazoles, benzoxazoles and benzothiazoles derivatives using ligand-free cobalt-nanoparticles: as potential anti-estrogen breast cancer agents, and study of their interactions with estrogen receptor by molecular docking
作者： Abdol R. Hajipour , Zahra Khorsandi , Maryam Mortazavi , Hossein Farrokhpour
DOI: 10.1039/C5RA22207A
关键词: Estrogen receptor 、 Breast cancer 、 Benzimidazole 、 Nanoparticle 、 Ligand 、 Chemistry 、 Organic chemistry 、 Cobalt 、 Anti estrogen 、 Cobalt oxide
摘要: A facile and high yielding method for the synthesis of 2-aryl benzoxazoles, benzimidazole benzothiazoles is reported employing cobalt oxide nanoparticles. The nanoparticles were used as a convenient, green, easy available highly efficient heterogeneous nano catalyst which promoted cyclization cross-coupling reactions without ligands and/or additives. This procedure has advantages such simplicity work-up, eco-friendly reaction medium, low cost mild conditions reaction. In addition to, binding modes synthesized compounds to estrogen receptor studied by molecular docking investigate their potentially anti breast cancer activity.
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