Dental mold: a novel formulation to treat common dental disorders.

摘要: Oral administration of antibiotics to treat dental problems mostly yields slow actions due onset and hepatic “first-pass.” Again, commonly used paints are generally washed out by saliva within few hours application. To overcome the challenges, polymeric molds be placed on an affected tooth (during carries gum problems) were prepared evaluated in vitro for sustained drug release prolonged local action. Here, amoxicillin trihydrate lidocaine hydrochloride as model drugs. Dental using corn zein, carbopol 934 P, karaya powder, poloxamer 407 mixing solvent evaporation technique. Different physicochemical evaluation studies such adhesion test, surface pH, swelling index, drug-distribution pattern carried out. Percentage varied from 56% 93%. Average strength mean initial pH formulations 50 g 6.5, respectively. As assessed scanning electron microscopy, distribution was uniform throughout matrix. Cumulative percentage simulated 98% 50%, In drug-release revealed sustained-release patterns drugs at least 24 h. The stability study shows that stable following conditions per ICH guideline. formulation is a novel approach deliver drug(s) period action upon its application tooth.