Role of Helicobacter pylori infection among offspring or siblings of gastric cancer patients.

摘要: A positive family history is an increased risk factor for gastric cancer within members, and one of the possible causes this intrafamilial clustering Helicobacter pylori infection. Our study examined prevalence H. infection, serum antibodies to CagA VacA atrophic gastritis and/or intestinal metaplasia in offspring or siblings patients. total 726 subjects included 300 relatives separate patients 426 controls. All underwent upper gastrointestinal endoscopic examination with a rapid urease test. Blood samples were obtained test presence proteins pylori. The infection was higher (75.3%) than controls (60.1%), adjusted odds ratio 2.1 (95% CI 1.5-2.9). When either 2 more members patients, much compared There no specific relationship between VacA, Atrophic frequently found pylori-infected (26.1%) (12.9%). These results strongly support role familial aggregation cancer. prophylactic eradication may be clinically beneficial.